Wenlei Ye, PhD

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+1 415 476-0421
Publications: 

Structure, function and pharmacology of human itch GPCRs.

Nature

Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL

Chloride channels regulate differentiation and barrier functions of the mammalian airway.

eLife

He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY

Abstract 53: Missense Pathogenic Variants in ANO1 Predispose to Moyamoya Disease.

Stroke

Amélie Pinard, Mu He, Jill A Rosenfeld, Wenlei Ye, Stéphanie Guey, Scott Hickey, Andrea M Lewis, Alana C Cecchi, Dongchuan Guo, Chaker Aloui, Michael J Bamshad, Deborah A Nickerson, Elisabeth Tournier-Lasserve, Dianna M Milewicz

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.

Cell reports

Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y

Chemically induced vesiculation as a platform for studying TMEM16F activity.

Proceedings of the National Academy of Sciences of the United States of America

Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY

Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers.

Scientific reports

Ye W, Tu YH, Cooper AJ, Zhang Z, Katritch V, Liman ER

Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.

Proceedings of the National Academy of Sciences of the United States of America

Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY

An evolutionarily conserved gene family encodes proton-selective ion channels.

Science (New York, N.Y.)

Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER

Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

Nature

Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY

Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America

He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY

The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction.

Proceedings of the National Academy of Sciences of the United States of America

Ye W, Chang RB, Bushman JD, Tu YH, Mulhall EM, Wilson CE, Cooper AJ, Chick WS, Hill-Eubanks DC, Nelson MT, Kinnamon SC, Liman ER

A proton current associated with sour taste: distribution and functional properties.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Bushman JD, Ye W, Liman ER

K+ channels and the cAMP-PKA pathway modulate TGF-beta1-induced migration of rat vascular myofibroblasts.

Journal of cellular physiology

Liu YR, Ye WL, Zeng XM, Ren WH, Zhang YQ, Mei YA