Lily Jan, PhD | Jan Lab

Pinard A, Ye W, Fraser SM, Rosenfeld JA, Pichurin P, Hickey SE, Guo D, Cecchi AC, Boerio ML, Guey S, Aloui C, Lee K, Kraemer M, Alyemni SO, University of Washington Center for Mendelian Genomics, Bamshad MJ, Nickerson DA, Tournier-Lasserve E, Haider S, Jin SC, Smith ER, Kahle KT, Jan LY, He M, Milewicz DM

Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.

Nature communications

Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY

SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.

bioRxiv : the preprint server for biology

Tuomivaara ST, Teo CF, Jan YN, Jan LY, Wiita AP

The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling.

The Journal of cell biology

O'Brien CE, Younger SH, Jan LY, Jan YN

A photo-switchable assay system for dendrite degeneration and repair in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America

Liu HH, Hsu CH, Jan LY, Jan YN

Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Lin King YH, Chen C, Lin King JV, Simms J, Glasscock E, Yang SB, Jan YN, Jan LY

Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes.

Molecular cell

Ye W, Zhao H, Dai Y, Wang Y, Lo YH, Jan LY, Lee CH

Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development.

eLife

Jaszczak JS, DeVault L, Jan LY, Jan YN

Identification of a conserved drug binding pocket in TMEM16 proteins.

Research square

Cheng Y, Feng S, Puchades C, Ko J, Figueroa E, Chen Y, Wu H, Gu S, Han T, Li J, Ho B, Shoichet B, Jan YN, Jan L

Structure, function and pharmacology of human itch GPCRs.

Nature

Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL

Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway.

eLife

Chou SM, Li KX, Huang MY, Chen C, Lin King YH, Li GG, Zhou W, Teo CF, Jan YN, Jan LY, Yang SB

TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.

Proceedings of the National Academy of Sciences of the United States of America

Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY

TMEM16K is an interorganelle regulator of endosomal sorting.

Nature communications

Petkovic M, Oses-Prieto J, Burlingame A, Jan LY, Jan YN

Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays.

Nature Physics

Juan GRR, Mathijssen AJTM, He M, Jan L, Marshall W, Prakash M

Chloride channels regulate differentiation and barrier functions of the mammalian airway.

eLife

He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY

Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms.

Annual review of neuroscience

Jin P, Jan LY, Jan YN

Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors.

Genes & development

Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.

eLife

Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.

Cell reports

Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y

Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity.

eLife

Ye W, Han TW, He M, Jan YN, Jan LY

TMEM16B calcium-activated chloride channels regulate action potential firing in lateral septum and aggression in male mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Wang L, Simms J, Peters CJ, Fontaine MT, Li K, Gill TM, Nung Jan Y, Jan LY

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.

Neuron

Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.

Cell reports

Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y

The multifaceted role of TMEM16A in cancer.

Cell calcium

Crottès D, Jan LY

TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.

Proceedings of the National Academy of Sciences of the United States of America

Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.

Neuron

Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY

Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity.

Proceedings of the National Academy of Sciences of the United States of America

Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN

The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.

Neuron

Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN

Chemically induced vesiculation as a platform for studying TMEM16F activity.

Proceedings of the National Academy of Sciences of the United States of America

Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY

Far away from the lamppost.

PLoS biology

Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT

Activation of orexin system facilitates anesthesia emergence and pain control.

Proceedings of the National Academy of Sciences of the United States of America

Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY

Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics.

The Journal of general physiology

Jan LY, Jan YN

Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.

Genes & development

DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN

Force-activated ion channels in close-up.

Nature

Jan YN, Jan LY

The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel.

Neuron

Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY

Force-activated ion channels in close-up.

Nature

Jan YN, Jan LY

Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.

Proceedings of the National Academy of Sciences of the United States of America

Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY

Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

Nature

Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY

Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America

He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY

Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.

Cell reports

Meltzer S, Bagley JA, Perez GL, O'Brien CE, DeVault L, Guo Y, Jan LY, Jan YN

Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.

Neuron

Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, Jan LY, Yang H

Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.

Cell reports

Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.

Nature

Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y

Age-dependent diastolic heart failure in an in vivo Drosophila model.

eLife

Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN

TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.

Neuron

Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN

A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN

N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels.

The Journal of physiology

Thayer DA, Yang SB, Jan YN, Jan LY

In vivo dendrite regeneration after injury is different from dendrite development.

Genes & development

Thompson-Peer KL, DeVault L, Li T, Jan LY, Jan YN

Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.

Proceedings of the National Academy of Sciences of the United States of America

Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Göpfert MC, Jan LY, Jan YN, Wang Z

Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.

Neuron

Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN

Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons.

Neuron

Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.

Science translational medicine

Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY, Perretti M

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.

Cell reports

Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel.

Cell

Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.

Nature neuroscience

Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY

Regulation of axon regeneration by the RNA repair and splicing pathway.

Nature neuroscience

Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN

The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion.

eLife

Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels.

Proceedings of the National Academy of Sciences of the United States of America

Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY

Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

Proceedings of the National Academy of Sciences of the United States of America

Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien RW, Jan LY, Fu YH, Ptácek LJ

MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.

Neuron

Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN

Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila.

Cell reports

Gorczyca DA, Younger S, Meltzer S, Kim SE, Cheng L, Song W, Lee HY, Jan LY, Jan YN

Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae.

eLife

Zhang W, Yan Z, Li B, Jan LY, Jan YN

Common variants associated with general and MMR vaccine-related febrile seizures.

Nature genetics

Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, Eitson JL, Hollegaard MV, Svanström H, Vestergaard M, Hougaard DM, Schoggins JW, Jan LY, Melbye M, Hviid A

Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.

Genes & development

Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN

Targeting potassium channels in cancer.

The Journal of cell biology

Huang X, Jan LY

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.

eLife

Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, Yang H

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

Nature medicine

Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM

An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.

Nature communications

Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X

Krüppel mediates the selective rebalancing of ion channel expression.

Neuron

Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis GW

Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.

Proceedings of the National Academy of Sciences of the United States of America

Rumpf S, Bagley JA, Thompson-Peer KL, Zhu S, Gorczyca D, Beckstead RB, Jan LY, Jan YN

Lily Jan.

Current biology : CB

Jan L

Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila.

Neuron

Han C, Song Y, Xiao H, Wang D, Franc NC, Jan LY, Jan YN

A PDF/NPF neuropeptide signaling circuitry of male Drosophila melanogaster controls rival-induced prolonged mating.

Neuron

Kim WJ, Jan LY, Jan YN

Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila.

Nature neuroscience

Yuan Q, Song Y, Yang CH, Jan LY, Jan YN

Subdued, a TMEM16 family Ca²?-activated Cl?channel in Drosophila melanogaster with an unexpected role in host defense.

eLife

Wong XM, Younger S, Peters CJ, Jan YN, Jan LY

Conduits of life's spark: a perspective on ion channel research since the birth of neuron.

Neuron

Isacoff EY, Jan LY, Minor DL

Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells.

eLife

Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S

Making antisense of pain.

Nature neuroscience

Han TW, Jan LY

Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.

Proceedings of the National Academy of Sciences of the United States of America

Zhang W, Yan Z, Jan LY, Jan YN

TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.

Nature neuroscience

Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).

Proceedings of the National Academy of Sciences of the United States of America

Tien J, Lee HY, Minor DL, Jan YN, Jan LY

Increased neuronal activity fragments the Golgi complex.

Proceedings of the National Academy of Sciences of the United States of America

Thayer DA, Jan YN, Jan LY

Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation.

Nature

Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE, Meltzer S, Jan LY, Jan YN

Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons.

Neuron

Ori-McKenney KM, Jan LY, Jan YN

TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.

Cell

Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.

Proceedings of the National Academy of Sciences of the United States of America

Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR

Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.

Neuron

Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

Genes & development

Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY

Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.

Genes & development

Song Y, Ori-McKenney KM, Zheng Y, Han C, Jan LY, Jan YN

Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals.

Nature neuroscience

Kim WJ, Jan LY, Jan YN

Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons.

Neuron

Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY

Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.

Current opinion in neurobiology

Lee HY, Jan LY

Local generation of glia is a major astrocyte source in postnatal cortex.

Nature

Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY

Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.

Neuron

Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN

Voltage-gated potassium channels and the diversity of electrical signalling.

The Journal of physiology

Jan LY, Jan YN

Ca2+-activated Cl- channels at a glance.

Journal of cell science

Berg J, Yang H, Jan LY

Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers.

The Journal of physiology

Yang SB, Mclemore KD, Tasic B, Luo L, Jan YN, Jan LY

Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space.

Neuron

Han C, Wang D, Soba P, Zhu S, Lin X, Jan LY, Jan YN

Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.

Proceedings of the National Academy of Sciences of the United States of America

Zhu S, Barshow S, Wildonger J, Jan LY, Jan YN

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.

Journal of molecular medicine (Berlin, Germany)

Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY

Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein.

Neuron

Lee HY, Ge WP, Huang W, He Y, Wang GX, Rowson-Baldwin A, Smith SJ, Jan YN, Jan LY

International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels.

Pharmacological reviews

Huang F, Wong X, Jan LY

Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Lee SB, Bagley JA, Lee HY, Jan LY, Jan YN

Light-induced structural and functional plasticity in Drosophila larval visual system.

Science (New York, N.Y.)

Yuan Q, Xiang Y, Yan Z, Han C, Jan LY, Jan YN

Isolation and Expression Profile of the Ca-Activated Chloride Channel-like Membrane Protein 6 Gene in Xenopus laevis.

Laboratory animal research

Lee RM, Ryu RH, Jeong SW, Oh SJ, Huang H, Han JS, Lee CH, Lee CJ, Jan LY, Jeong SM

Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila.

Development (Cambridge, England)

Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B

Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Han C, Jan LY, Jan YN

Cloning and heterologous expression of new xANO2 from Xenopus laevis.

Biochemical and biophysical research communications

Ryu RH, Oh SJ, Lee RM, Jeong SW, Jan LY, Lee CH, Lee CJ, Jeong SM

Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ye B, Kim JH, Yang L, McLachlan I, Younger S, Jan LY, Jan YN

Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.

Development (Cambridge, England)

Rumpf S, Lee SB, Jan LY, Jan YN

Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall.

Nature

Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN

Mechanisms of distribution and targeting of neuronal ion channels.

Current opinion in drug discovery & development

Thayer DA, Jan LY

The role of the TRP channel NompC in Drosophila larval and adult locomotion.

Neuron

Cheng LE, Song W, Looger LL, Jan LY, Jan YN

A twist on potassium channel gating.

Cell

Zhou W, Jan L

Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism.

Proceedings of the National Academy of Sciences of the United States of America

Young DM, Schenk AK, Yang SB, Jan YN, Jan LY

Branching out: mechanisms of dendritic arborization.

Nature reviews. Neuroscience

Jan YN, Jan LY

Studies on expression and function of the TMEM16A calcium-activated chloride channel.

Proceedings of the National Academy of Sciences of the United States of America

Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY

The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons.

Neuron

Parrish JZ, Xu P, Kim CC, Jan LY, Jan YN

Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex.

Neuron

Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH

Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis.

Proceedings of the National Academy of Sciences of the United States of America

Lee HH, Jan LY, Jan YN

A gate keeper for axonal transport.

Cell

Xiao S, Jan LY

Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.

Neuron

Yang CH, Rumpf S, Xiang Y, Gordon MD, Song W, Jan LY, Jan YN

G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation.

Proceedings of the National Academy of Sciences of the United States of America

Chung HJ, Ge WP, Qian X, Wiser O, Jan YN, Jan LY

Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels.

Proceedings of the National Academy of Sciences of the United States of America

Chung HJ, Qian X, Ehlers M, Jan YN, Jan LY

Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.

Proceedings of the National Academy of Sciences of the United States of America

Ge WP, Zhou W, Luo Q, Jan LY, Jan YN

Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.

Cell

Schroeder BC, Cheng T, Jan YN, Jan LY

The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels.

Genes & development

Wildonger J, Jan LY, Jan YN

Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons.

Nature cell biology

Zheng Y, Wildonger J, Ye B, Zhang Y, Kita A, Younger SH, Zimmerman S, Jan LY, Jan YN

Thrilling moment of an inhibitory channel.

Neuron

Yang SB, Jan LY

Genetic and physiologic dissection of the vertebrate cardiac conduction system.

PLoS biology

Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY

Drosophila egg-laying site selection as a system to study simple decision-making processes.

Science (New York, N.Y.)

Yang CH, Belawat P, Hafen E, Jan LY, Jan YN

Stoichiometry of Kir channels with phosphatidylinositol bisphosphate.

Channels (Austin, Tex.)

Jin T, Sui JL, Rosenhouse-Dantsker A, Chan KW, Jan LY, Logothetis DE

Foxn4 directly regulates tbx2b expression and atrioventricular canal formation.

Genes & development

Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY

Retrospective: Seymour Benzer (1921-2007).

Science (New York, N.Y.)

Jan YN, Jan L

Identification of yeast proteins necessary for cell-surface function of a potassium channel.

Proceedings of the National Academy of Sciences of the United States of America

Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M

Growing dendrites and axons differ in their reliance on the secretory pathway.

Cell

Ye B, Zhang Y, Song W, Younger SH, Jan LY, Jan YN

Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons.

The Journal of biological chemistry

Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D

Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.

Nature neuroscience

Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N

Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization.

Neuron

Soba P, Zhu S, Emoto K, Younger S, Yang SJ, Yu HH, Lee T, Jan LY, Jan YN

Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites.

Genes & development

Parrish JZ, Emoto K, Jan LY, Jan YN

Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae.

Proceedings of the National Academy of Sciences of the United States of America

Song W, Onishi M, Jan LY, Jan YN

Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recycling.

The Journal of biological chemistry

Gong Q, Weide M, Huntsman C, Xu Z, Jan LY, Ma D

Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions.

Cell

Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY

HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

Katarina K, Daniela P, Peter N, Marianna R, Pavlina C, Stepanka P, Jan L, Ludmila T, Michal A, Marie C

Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology.

Development (Cambridge, England)

Grueber WB, Ye B, Yang CH, Younger S, Borden K, Jan LY, Jan YN

Structure prediction for the down state of a potassium channel voltage sensor.

Nature

Grabe M, Lai HC, Jain M, Jan YN, Jan LY

Channeling to the nucleus.

Neuron

Chung HJ, Jan LY

Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.

Cell

Kuo CT, Mirzadeh Z, Soriano-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY, Jan YN

The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting.

Neuron

Gu C, Zhou W, Puthenveedu MA, Xu M, Jan YN, Jan LY

SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes.

Proceedings of the National Academy of Sciences of the United States of America

Fay AJ, Qian X, Jan YN, Jan LY

Turning G proteins on and off using peptide ligands.

ACS chemical biology

Ja WW, Wiser O, Austin RJ, Jan LY, Roberts RW

The secretory pathway and neuron polarization.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ye B, Zhang YW, Jan LY, Jan YN

Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.

Science (New York, N.Y.)

Raab-Graham KF, Haddick PC, Jan YN, Jan LY

The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons.

Genes & development

Kim MD, Jan LY, Jan YN

Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.

Proceedings of the National Academy of Sciences of the United States of America

Bichet D, Grabe M, Jan YN, Jan LY

K+ channel selectivity depends on kinetic as well as thermodynamic factors.

Proceedings of the National Academy of Sciences of the United States of America

Grabe M, Bichet D, Qian X, Jan YN, Jan LY

The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance.

Nature

Emoto K, Parrish JZ, Jan LY, Jan YN

Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning.

Neuron

Kuo CT, Zhu S, Younger S, Jan LY, Jan YN

The distribution and targeting of neuronal voltage-gated ion channels.

Nature reviews. Neuroscience

Lai HC, Jan LY

Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains.

Proceedings of the National Academy of Sciences of the United States of America

Chung HJ, Jan YN, Jan LY

Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN.

Neuron

Wiser O, Qian X, Ehlers M, Ja WW, Roberts RW, Reuveny E, Jan YN, Jan LY

Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites.

Genes & development

Parrish JZ, Kim MD, Jan LY, Jan YN

International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.

Pharmacological reviews

Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA

Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.

Proceedings of the National Academy of Sciences of the United States of America

Surti TS, Huang L, Jan YN, Jan LY, Cooper EC

Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition.

Cell

Huang CS, Shi SH, Ule J, Ruggiu M, Barker LA, Darnell RB, Jan YN, Jan LY

Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling.

Proceedings of the National Academy of Sciences of the United States of America

Kuo CT, Jan LY, Jan YN

The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.

Neuron

Lai HC, Grabe M, Jan YN, Jan LY

A potassium channel, the M-channel, as a therapeutic target.

Current opinion in investigational drugs (London, England : 2000)

Surti TS, Jan LY

Mammalian electrophysiology on a microfluidic platform.

Proceedings of the National Academy of Sciences of the United States of America

Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee LP

Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.

Molecular biology of the cell

Roegiers F, Jan LY, Jan YN

A fluorescent probe designed for studying protein conformational change.

Proceedings of the National Academy of Sciences of the United States of America

Cohen BE, Pralle A, Yao X, Swaminath G, Gandhi CS, Jan YN, Kobilka BK, Isacoff EY, Jan LY

Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.

Genes & development

Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN

A quantitative assessment of models for voltage-dependent gating of ion channels.

Proceedings of the National Academy of Sciences of the United States of America

Grabe M, Lecar H, Jan YN, Jan LY

APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.

Current biology : CB

Shi SH, Cheng T, Jan LY, Jan YN

Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons.

Cell

Emoto K, He Y, Ye B, Grueber WB, Adler PN, Jan LY, Jan YN

Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1).

Proceedings of the National Academy of Sciences of the United States of America

Shi SH, Cox DN, Wang D, Jan LY, Jan YN

The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation.

Proceedings of the National Academy of Sciences of the United States of America

Shi SH, Cheng T, Jan LY, Jan YN

NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection.

Proceedings of the National Academy of Sciences of the United States of America

Lin YF, Raab-Graham K, Jan YN, Jan LY

Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity.

Proceedings of the National Academy of Sciences of the United States of America

Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY

Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification.

Genes & development

Moore AW, Roegiers F, Jan LY, Jan YN

Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.

Current biology : CB

Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN

Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.

Neuron

Li HS, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, Temple S, Jan LY, Jan YN

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.

Pharmacological reviews

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS

Merging functional studies with structures of inward-rectifier K(+) channels.

Nature reviews. Neuroscience

Bichet D, Haass FA, Jan LY

Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture.

Proceedings of the National Academy of Sciences of the United States of America

Hong Y, Ackerman L, Jan LY, Jan YN

The control of dendrite development.

Neuron

Jan YN, Jan LY

Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons.

Neuron

Rothenberg ME, Rogers SL, Vale RD, Jan LY, Jan YN

A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels.

Science (New York, N.Y.)

Gu C, Jan YN, Jan LY

Answers and questions from the KvAP structures.

Neuron

Cohen BE, Grabe M, Jan LY

Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.

Proceedings of the National Academy of Sciences of the United States of America

Pei L, Wiser O, Slavin A, Mu D, Powers S, Jan LY, Hoey T

ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C.

Neuron

Hu K, Huang CS, Jan YN, Jan LY

Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage.

Current biology : CB

Justice N, Roegiers F, Jan LY, Jan YN

Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion.

Current biology : CB

Grueber WB, Ye B, Moore AW, Jan LY, Jan YN

M-channels: neurological diseases, neuromodulation, and drug development.

Archives of neurology

Cooper EC, Jan LY

Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons.

Cell

Grueber WB, Jan LY, Jan YN

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.

Cancer cell

Mu D, Chen L, Zhang X, See LH, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KC, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, Jan LY, McCombie WR, Wigler MH, Powers S

The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.

Developmental cell

Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.

Cell

Shi SH, Jan LY, Jan YN

Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences.

Proceedings of the National Academy of Sciences of the United States of America

Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, Basbaum AI

hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology.

Science (New York, N.Y.)

Moore AW, Jan LY, Jan YN

ER transport signals and trafficking of potassium channels and receptors.

Current opinion in neurobiology

Ma D, Jan LY

Tiling of the Drosophila epidermis by multidendritic sensory neurons.

Development (Cambridge, England)

Grueber WB, Jan LY, Jan YN

Probing protein electrostatics with a synthetic fluorescent amino acid.

Science (New York, N.Y.)

Cohen BE, McAnaney TB, Park ES, Jan YN, Boxer SG, Jan LY

Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart.

Neuron

Ma D, Zerangue N, Raab-Graham K, Fried SR, Jan YN, Jan LY

M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Cooper EC, Harrington E, Jan YN, Jan LY

Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.

Nature

Hong Y, Stronach B, Perrimon N, Jan LY, Jan YN

Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary.

Proceedings of the National Academy of Sciences of the United States of America

Cox DN, Seyfried SA, Jan LY, Jan YN

Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Roegiers F, Younger-Shepherd S, Jan LY, Jan YN

Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.

Proceedings of the National Academy of Sciences of the United States of America

Margeta-Mitrovic M, Jan YN, Jan LY

Ligand-induced signal transduction within heterodimeric GABA(B) receptor.

Proceedings of the National Academy of Sciences of the United States of America

Margeta-Mitrovic M, Jan YN, Jan LY

Asymmetric cell division in the Drosophila nervous system.

Nature reviews. Neuroscience

Jan YN, Jan LY

Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila.

Developmental cell

Brenman JE, Gao FB, Jan LY, Jan YN

Dendrites.

Genes & development

Jan YN, Jan LY

Expression Profile of Aging and Oxidative Stress Response in Drosophila melanogaster.

TheScientificWorldJournal

Zou S, Meadows S, Sharp L, Jan LY, Jan YN

Controlling potassium channel activities: Interplay between the membrane and intracellular factors.

Proceedings of the National Academy of Sciences of the United States of America

Yi BA, Minor DL, Lin YF, Jan YN, Jan LY

Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.

Proceedings of the National Academy of Sciences of the United States of America

Ruan Y, Tecott L, Jiang MM, Jan LY, Jan YN

Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.

Nature neuroscience

Lu T, Ting AY, Mainland J, Jan LY, Schultz PG, Yang J

Yeast screen for constitutively active mutant G protein-activated potassium channels.

Neuron

Yi BA, Lin YF, Jan YN, Jan LY

Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America

Zerangue N, Malan MJ, Fried SR, Dazin PF, Jan YN, Jan LY, Schwappach B

Adherens junctions inhibit asymmetric division in the Drosophila epithelium.

Nature

Lu B, Roegiers F, Jan LY, Jan YN

Role of ER export signals in controlling surface potassium channel numbers.

Science (New York, N.Y.)

Ma D, Zerangue N, Lin YF, Collins A, Yu M, Jan YN, Jan LY

Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.

Nature cell biology

Roegiers F, Younger-Shepherd S, Jan LY, Jan YN

Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America

Zou S, Meadows S, Sharp L, Jan LY, Jan YN

Control of dendritic field formation in Drosophila: the roles of flamingo and competition between homologous neurons.

Neuron

Gao FB, Kohwi M, Brenman JE, Jan LY, Jan YN

Signalling mechanisms: a decade of signalling.

Current opinion in neurobiology

Jan LY, Stevens CF

A genomewide survey of basic helix-loop-helix factors in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Moore AW, Barbel S, Jan LY, Jan YN

Heartfelt crosstalk: desensitization of the GIRK current.

Nature cell biology

Jan LY, Jan YN

Taking apart the gating of voltage-gated K+ channels.

Neuron

Yi BA, Jan LY

The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.

Cell

Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY, Berger JM

A trafficking checkpoint controls GABA(B) receptor heterodimerization.

Neuron

Margeta-Mitrovic M, Jan YN, Jan LY

Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.

Proceedings of the National Academy of Sciences of the United States of America

Sun Y, Jan LY, Jan YN

Mouse numb is an essential gene involved in cortical neurogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Zhong W, Jiang MM, Schonemann MD, Meneses JJ, Pedersen RA, Jan LY, Jan YN

A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ.

Genetics

Abdelilah-Seyfried S, Chan YM, Zeng C, Justice NJ, Younger-Shepherd S, Sharp LE, Barbel S, Meadows SA, Jan LY, Jan YN

Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.

Proceedings of the National Academy of Sciences of the United States of America

Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY

Molecular basis for K(ATP) assembly: transmembrane interactions mediate association of a K+ channel with an ABC transporter.

Neuron

Schwappach B, Zerangue N, Jan YN, Jan LY

An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1.

Proceedings of the National Academy of Sciences of the United States of America

Zerangue N, Jan YN, Jan LY

Polarity in cell division: what frames thy fearful asymmetry?

Cell

Jan YN, Jan LY

Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.

The EMBO journal

Lin YF, Jan YN, Jan LY

Control of cell divisions in the nervous system: symmetry and asymmetry.

Annual review of neuroscience

Lu B, Jan L, Jan YN

Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division.

Molecular cell

Lu B, Ackerman L, Jan LY, Jan YN

Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.

Current biology : CB

Lu B, Usui T, Uemura T, Jan L, Jan YN

Genes regulating dendritic outgrowth, branching, and routing in Drosophila.

Genes & development

Gao FB, Brenman JE, Jan LY, Jan YN

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

Neuron

Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M

Asymmetry across species.

Nature cell biology

Jan YN, Jan LY

Ion channel genes and human neurological disease: recent progress, prospects, and challenges.

Proceedings of the National Academy of Sciences of the United States of America

Cooper EC, Jan LY

Transmembrane structure of an inwardly rectifying potassium channel.

Cell

Minor DL, Masseling SJ, Jan YN, Jan LY

Immunohistochemical localization of GABA(B) receptors in the rat central nervous system.

The Journal of comparative neurology

Margeta-Mitrovic M, Mitrovic I, Riley RC, Jan LY, Basbaum AI

A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.

Neuron

Zerangue N, Schwappach B, Jan YN, Jan LY

Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization.

Current biology : CB

Knoblich JA, Jan LY, Jan YN

Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors.

Cell

Lu B, Rothenberg M, Jan LY, Jan YN

Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.

Proceedings of the National Academy of Sciences of the United States of America

Chuang HH, Yu M, Jan YN, Jan LY

The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.

Proceedings of the National Academy of Sciences of the United States of America

Zeng C, Justice NJ, Abdelilah S, Chan YM, Jan LY, Jan YN

Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system.

Development (Cambridge, England)

Sun Y, Jan LY, Jan YN

Asymmetric cell division: lessons from flies and worms.

Current opinion in genetics & development

Lu B, Jan LY, Jan YN

Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.

Genes & development

Shen CP, Knoblich JA, Chan YM, Jiang MM, Jan LY, Jan YN

Molecular basis for interactions of G protein betagamma subunits with effectors.

Science (New York, N.Y.)

Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, Iyengar R, Miller RJ, Jan LY, Lefkowitz RJ, Hamm HE

Asymmetric cell division.

Nature

Jan YN, Jan LY

G-protein signaling: fine-tuning signaling kinetics.

Current biology : CB

Zerangue N, Jan LY

Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.

Genes & development

Zeng C, Younger-Shepherd S, Jan LY, Jan YN

Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Cooper EC, Milroy A, Jan YN, Jan LY, Lowenstein DH

Epilepsy genes: excitement traced to potassium channels.

Nature genetics

Stoffel M, Jan LY

Humble starts and conserved themes in neurogenetic studies.

Harvey lectures

Jan YN, Jan LY

Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo.

Molecular and cellular biology

Chien CT, Wang S, Rothenberg M, Jan LY, Jan YN

Serendipity, the principle of limited sloppiness, and neural development.

The International journal of developmental biology

Jan YN, Jan LY

Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.

The Journal of biological chemistry

Vivaudou M, Chan KW, Sui JL, Jan LY, Reuveny E, Logothetis DE

Ways and means for left shifts in the MaxiK channel.

Proceedings of the National Academy of Sciences of the United States of America

Jan LY, Jan YN

Voltage-gated and inwardly rectifying potassium channels.

The Journal of physiology

Jan LY, Jan YN

Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.

Proceedings of the National Academy of Sciences of the United States of America

Luo L, Lee T, Tsai L, Tang G, Jan LY, Jan YN

The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.

Proceedings of the National Academy of Sciences of the United States of America

Knoblich JA, Jan LY, Jan YN

Breaking symmetry in the CNS.

Trends in cell biology

Li P, Yang X, Wasser M, Cai Y, Chia W, Shen CP, Jan LY, Jan YN

Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.

Development (Cambridge, England)

Wang S, Younger-Shepherd S, Jan LY, Jan YN

Xath5 participates in a network of bHLH genes in the developing Xenopus retina.

Neuron

Kanekar S, Perron M, Dorsky R, Harris WA, Jan LY, Jan YN, Vetter ML

Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.

Proceedings of the National Academy of Sciences of the United States of America

Slesinger PA, Stoffel M, Jan YN, Jan LY

The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.

Development (Cambridge, England)

Doherty D, Jan LY, Jan YN

G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons.

Neuron

Lüscher C, Jan LY, Stoffel M, Malenka RC, Nicoll RA

Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila.

Cell

Shen CP, Jan LY, Jan YN

Regulation of IRK3 inward rectifier K+ channel by m1 acetylcholine receptor and intracellular magnesium.

Cell

Chuang H, Jan YN, Jan LY

Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel.

Proceedings of the National Academy of Sciences of the United States of America

Collins A, Chuang H, Jan YN, Jan LY

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.

Development (Cambridge, England)

Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN

Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels.

FEBS letters

Huang CL, Jan YN, Jan LY

Receptor-regulated ion channels.

Current opinion in cell biology

Jan LY, Jan YN

Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.

Proceedings of the National Academy of Sciences of the United States of America

Yang J, Yu M, Jan YN, Jan LY

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.

Proceedings of the National Academy of Sciences of the United States of America

Signorini S, Liao YJ, Duncan SA, Jan LY, Stoffel M

Rho family GTP-binding proteins in growth cone signalling.

Current opinion in neurobiology

Luo L, Jan LY, Jan YN

Asymmetric segregation of the Drosophila numb protein during mitosis: facts and speculations.

Cold Spring Harbor symposia on quantitative biology

Knoblich JA, Jan LY, Jan YN

Cloned potassium channels from eukaryotes and prokaryotes.

Annual review of neuroscience

Jan LY, Jan YN

Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle.

Development (Cambridge, England)

Clark IE, Jan LY, Jan YN

Regions responsible for the assembly of inwardly rectifying potassium channels.

Cell

Tinker A, Jan YN, Jan LY

Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Liao YJ, Jan YN, Jan LY

Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.

Proceedings of the National Academy of Sciences of the United States of America

Chien CT, Hsiao CD, Jan LY, Jan YN

frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance.

Cell

Kolodziej PA, Timpe LC, Mitchell KJ, Fried SR, Goodman CS, Jan LY, Jan YN

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.

Proceedings of the National Academy of Sciences of the United States of America

Frise E, Knoblich JA, Younger-Shepherd S, Jan LY, Jan YN

Role of inscuteable in orienting asymmetric cell divisions in Drosophila.

Nature

Kraut R, Chia W, Jan LY, Jan YN, Knoblich JA

Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.

The EMBO journal

Fakler B, Schultz JH, Yang J, Schulte U, Brandle U, Zenner HP, Jan LY, Ruppersberg JP

Membrane permeability.

Current opinion in cell biology

Jan LY, Jan YN

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.

Neuron

Zhong W, Feder JN, Jiang MM, Jan LY, Jan YN

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch.

Neuron

Guo M, Jan LY, Jan YN

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.

Nature

Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

Genes & development

Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN

Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K(+)-selective permeation.

Biophysical journal

Reuveny E, Jan YN, Jan LY

Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels.

Neuron

Slesinger PA, Patil N, Liao YJ, Jan YN, Jan LY, Cox DR

A strongly inwardly rectifying K+ channel that is sensitive to ATP.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Collins A, German MS, Jan YN, Jan LY, Zhao B

Small GTPases in axon outgrowth.

Perspectives on developmental neurobiology

Luo L, Jan L, Jan YN

Determination of the subunit stoichiometry of an inwardly rectifying potassium channel.

Neuron

Yang J, Jan YN, Jan LY

Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.

Neuron

Huang CL, Slesinger PA, Casey PJ, Jan YN, Jan LY

Identification of structural elements involved in G protein gating of the GIRK1 potassium channel.

Neuron

Slesinger PA, Reuveny E, Jan YN, Jan LY

dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.

The EMBO journal

Feger G, Vaessin H, Su TT, Wolff E, Jan LY, Jan YN

Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits.

The Journal of biological chemistry

Xu J, Yu W, Jan YN, Jan LY, Li M

Asymmetric segregation of Numb and Prospero during cell division.

Nature

Knoblich JA, Jan LY, Jan YN

Mutations that affect the length, fasciculation, or ventral orientation of specific sensory axons in the Drosophila embryo.

Neuron

Kolodziej PA, Jan LY, Jan YN

Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.

Biochemical and biophysical research communications

Stoffel M, Tokuyama Y, Trabb JB, German MS, Tsaar ML, Jan LY, Polonsky KS, Bell GI

Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors.

Development (Cambridge, England)

Jarman AP, Sun Y, Jan LY, Jan YN

The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Klumpp DJ, Song EJ, Ito S, Sheng MH, Jan LY, Pinto LH

Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.

Neuron

Yang J, Jan YN, Jan LY

tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS.

Neuron

Guo M, Bier E, Jan LY, Jan YN

Maggot's hair and bug's eye: role of cell interactions and intrinsic factors in cell fate specification.

Neuron

Jan YN, Jan LY

The molecular organization of voltage-dependent K+ channels in vivo.

Progress in brain research

Sheng M, Jan YN, Jan L

Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila.

Genes & development

Jongens TA, Ackerman LD, Swedlow JR, Jan LY, Jan YN

Potassium channels and their evolving gates.

Nature

Jan LY, Jan YN

Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.

Proceedings of the National Academy of Sciences of the United States of America

Liu H, Wang H, Sheng M, Jan LY, Jan YN, Basbaum AI

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

Genes & development

Luo L, Liao YJ, Jan LY, Jan YN

daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo.

Development (Cambridge, England)

Vaessin H, Brand M, Jan LY, Jan YN

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells.

Cell

Rhyu MS, Jan LY, Jan YN

pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber.

Development (Cambridge, England)

Siegel V, Jongens TA, Jan LY, Jan YN

The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.

The EMBO journal

Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN

A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.

Molecular and cellular biology

Feder JN, Jan LY, Jan YN

Molecular basis of K+ channel inactivation gating.

EXS

Isacoff EY, Jan YN, Jan LY

deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product.

Genes & development

Bier E, Vaessin H, Younger-Shepherd S, Jan LY, Jan YN

deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination.

Cell

Younger-Shepherd S, Vaessin H, Bier E, Jan LY, Jan YN

The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system.

Development (Cambridge, England)

Rao Y, Bodmer R, Jan LY, Jan YN

prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila.

Cell

Vaessin H, Grell E, Wolff E, Bier E, Jan LY, Jan YN

The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.

The EMBO journal

Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN

Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos.

Genes & development

Blochlinger K, Bodmer R, Jan LY, Jan YN

A superfamily of ion channels.

Nature

Jan LY, Jan YN

Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes.

Nature

Isacoff EY, Jan YN, Jan LY

Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity.

Development (Cambridge, England)

Hay B, Jan LY, Jan YN

Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins.

Nature

Rao Y, Jan LY, Jan YN

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

Genes & development

Bier E, Jan LY, Jan YN

Immunological characterization of K+ channel components from the Shaker locus and differential distribution of splicing variants in Drosophila.

Neuron

Schwarz TL, Papazian DM, Carretto RC, Jan YN, Jan LY

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.

Cell

Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos.

Cell

Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN

Voltage-sensitive ion channels.

Cell

Jan LY, Jan YN

daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.

Cell

Caudy M, Vässin H, Brand M, Tuma R, Jan LY, Jan YN

A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.

Cell

Hay B, Jan LY, Jan YN

Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes.

Neuron

Timpe LC, Jan YN, Jan LY

Identification of a component of Drosophila polar granules.

Development (Cambridge, England)

Hay B, Ackerman L, Barbel S, Jan LY, Jan YN

The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.

Genes & development

Caudy M, Grell EH, Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN

Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila.

Nature

Blochlinger K, Bodmer R, Jack J, Jan LY, Jan YN

The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12.

Cell

Royden CS, Pirrotta V, Jan LY

Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila.

Cold Spring Harbor symposia on quantitative biology

Jan LY, Barbel S, Timpe L, Laffer C, Salkoff L, O'Farrell P, Jan YN

Publications